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To help capture a serial rapist-turned-killer, FBI Special Agent Don Eppes recruits his genius brother Charlie, who uses a mathematical equation to identify the killer's point of origin by working back from the crime scene locations.
Charlie accurately predicts where a band of bank robbers will strike next. But when Don and his team confront them, a massive shoot-out occurs leaving four people, including an officer, dead. The outcome disturbs Charlie and he retreats…
Various people in the L.A. area with seemingly nothing in common start to become extremely sick and die on the same day. Don fears bioterrorists may have released a deadly virus into the environment. While he tries to discover whether…
After an engineering student at CalSci is found dead from an apparent suicide, Charlie convinces Don to launch an investigation after he reads the student's thesis that asserted that the architecturally magnificent Cole Center in Los…
When a five-year-old girl is kidnapped from her birthday party, Don and Terry lead the investigation, but must rely on Charlie's help because the girl's father, Ethan, is also a mathematician. Charlie realizes the kidnapper's motive when…
While consulting with the NTSB at the scene of the wreck, Don learns that this tragedy is one of a series of recreated accidents involving railroad negligence. As is the pattern with the previous train wrecks, an undecipherable numerical…
Don learns that counterfeiters are at work producing small-denomination bills, and that they have taken an artist hostage to draw the images for the fake money. If the missing woman isn't located soon, Don fears that she will be killed…
A man wanted for stock fraud is found garroted in his apartment, and the crime is eerily similar to a murder committed a year earlier, a case in which Don closed when an ex-con confessed. Now, Don must re-investigate the old case to…
The city is in a panic as a sniper goes on a shooting spree and randomly kills several people, including a postal worker. The investigation reveals that more than one shooter is at work. As Charlie works the case, he's frustrated by a…
A truck carrying radioactive material is stolen, and the thieves threaten to set off a dirty bomb in L.A. in 12 hours if they aren't paid $20 million. While Don attempts to track down the truck, Charlie tries to come up with the most…
A senior computer-science researcher working on a classified government project is found murdered in his Hollywood Hills home and data has been stolen from his computer. The investigation reveals the victim was going through a bitter…
Don and Agent Weston of the NTSB investigate eyewitness accounts of a mysterious unidentified object flying dangerously close to downtown Los Angeles that has raised concern of a terrorist attack. After Charlie is recruited to help with…
A dangerous felon escapes when a prison bus crashes and the FBI has reason to fear he's intent on revenge against the witness whose testimony put him in jail. However, finding the elusive killer proves to be a complicated challenge. Don…
Season two has several changes to Don's FBI team: Terry Lake is reassigned to Washington and two new members join Don and David Sinclair: Megan Reeves and Colby Granger. Charlie is challenged on one of his long-standing mathematical workpieces and starts work on a new theory, cognitive emergence theory.
Charlie and Amita intensify their relationship, as do Larry and Megan, especially after Megan's kidnapping. Amita has trouble adjusting to her new role as a CalSci professor, and Larry announces his leave of absence; he will be on the International Space Station for six months, which greatly distresses Charlie.
